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Nitric oxide formation versus scavenging: the red blood cell balancing act.
Nitric oxide (NO) is a key modulator of vascular homeostasis controlling critical functions related to blood flow, respiration, cell death and proliferation, and protecting the vasculature fromExpand
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Peroxiredoxin-2 recycling is inhibited during erythrocyte storage.
AIMS Transfusion with stored red blood cells (RBCs) is associated with increased morbidity and mortality. Peroxiredoxin-2 (Prx-2) is a primary RBC antioxidant that limits hydrogen peroxideExpand
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Mechanism of faster NO scavenging by older stored red blood cells☆
The blood storage lesion involves morphological and biochemical changes of red blood cells (RBCs) that occur during storage. These include conversion of the biconcave disc morphology to a sphericalExpand
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Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage.
Transfusion of stored red blood cells (RBCs) is associated with increased morbidity and mortality in trauma patients. Pro-oxidant, pro-inflammatory, and nitric oxide (NO) scavenging properties ofExpand
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Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity.
Storage of erythrocytes in blood banks is associated with biochemical and morphological changes to RBCs (red blood cells). It has been suggested that these changes have potential negative clinicalExpand
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Elevated levels of NO are localized to distal airways in asthma.
The contribution of nitric oxide (NO) to the pathophysiology of asthma remains incompletely defined despite its established pro- and anti-inflammatory effects. Induction of the inducible nitric oxideExpand
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Effects of erythrocyte aging on nitric oxide and nitrite metabolism.
AIMS Recent studies have suggested that in addition to oxygen transport, red blood cells (RBC) are key regulators of vascular function by both inhibiting and promoting nitric oxide (NO)-mediatedExpand
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Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements.
BACKGROUND Storage-dependent damage to red blood cells (RBCs) varies significantly. Identifying RBC units that will undergo higher levels of hemolysis during storage may allow for more efficientExpand
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P31: The effects of red blood cell age on nitric oxide and nitrite-dependent signaling: Implications for transfusion related toxicity
Background RBC are critical hubs for regulated NO-homeostasis, affecting both inhibition (NO and nitrite oxidation) and stimulatory (nitrite-reduction to NO) pathways. How RBC affect this balance,Expand