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Long QT syndrome (LQTS) is the prototype of the cardiac ion channelopathies which cause syncope and sudden death. LQT1, due to mutations of KCNQ1 (KVLQT1), is the most common form. This study describes the genotype-phenotype characteristics in 10 families with mutations of KCNQ1, including 5 novel mutations. One hundred and two families with a history of(More)
Fuzzy Rules have been shown to be very useful in modeling relationships between variables that have a high degree of uncertainty or ambiguity. A major question in regards to learning fuzzy rule bases is how to handle interactions between rules of overlapping coverage. Structures, such as Yager’s HPS (Hierarchical Prioritized Structure), have been proposed(More)
Cardiac arrhythmias cause 400 000 sudden deaths annually in the United States alone. Mutations in the cardiac sodium channel gene SCN5A on chromosome 3p21 cause cardiac arrhythmias and sudden death. In this study, we define an SCN5A mutation, S1103Y, in a white family associated with syncope, ventricular fibrillation, and sudden death. A very recent study(More)
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