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Aerobic copper-catalyzed organic reactions.
TLDR
The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and CuIII oxidation states allowing it to act through one-electron or two-Electron processes, which feature confer a remarkably broad range of activities allowing copper to catalyze the oxidation and oxidative union of many substrates.
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Aerobic Copper‐Catalyzed Organic Reactions
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Palladium-catalyzed nitromethylation of aryl halides: an orthogonal formylation equivalent.
TLDR
An efficient cross-coupling reaction of aryl halides and nitromethane was developed with the use of parallel microscale experimentation, providing a mild and convenient formylation method that is compatible with many functional groups.
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Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells
TLDR
A homoallylamine functionality is developed that can undergo a subsequent self-immolative β-elimination, creating a FA-responsive trigger that is capable of masking a phenol on a fluorophore or any other potential chemical scaffold for related imaging and/or therapeutic applications.
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Minimizing the amount of nitromethane in palladium-catalyzed cross-coupling with aryl halides.
TLDR
The present transformation provides high yields at relatively low temperatures and tolerates an array of functionality, including heterocycles and substantial steric encumbrance.
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Rapid quantification of the activating effects of hydrogen-bonding catalysts with a colorimetric sensor.
TLDR
Blue-shifts seen upon treatment of H-bonding catalysts with the colorimetric compound 7-methyl-2-phenylimidazo[1,2-a]pyrazin-3(7H)-one correlate well to the K(eq) of binding to the sensor.
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Quantification of Electrophilic Activation by Hydrogen-Bonding Organocatalysts
TLDR
The sensor provides an assessment of both the inherent reactivity of a catalyst architecture as well as the sensitivity of the reaction to changes within an architecture, whereas catalyst pKa values are a poor measure of reactivity, although correlations have been identified within catalyst classes.
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Nitroethylation of vinyl triflates and bromides.
TLDR
The resultant process provides a mild and convenient entry to nitroethylated products, which are versatile precursors to β,γ-unsaturated carbonyls, homoallylic amines, and nitrile oxides.
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Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection.
TLDR
A ligand-directed activity-based sensing (ABS) approach to CO detection through palladium-mediated carbonylation chemistry is reported, which enables imaging of CO release in live cell and brain settings, including monitoring of endogenous CO production that triggers presynaptic dopamine release in fly brains.
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Amino acid-dependent stability of the acyl linkage in aminoacyl-tRNA.
TLDR
Analysis of the half-lives of 12 natural aminoacyl-tRNAs shows that the stability of the acyl linkage is effectively determined only by the chemical nature of the amino acid side chain, and suggests that each amino acid plays an active role in determining its own stability in the acy linkage to tRNA, but that EF-Tu overrides this individuality and protects the acyle linkage stability for protein synthesis on the ribosome.
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