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We present two simple search methods for computing a sample Nash equilibrium in a normal-form game: one for 2player games and one for n-player games. We test these algorithms on many classes of games, and show that they perform well against the state of the art– the Lemke-Howson algorithm for 2-player games, and Simplicial Subdivision and Govindan-Wilson(More)
For the problem of online real-time scheduling of jobs on a single processor, previous work presents matching upper and lower bounds on the competitive ratio that can be achieved by a deterministic algorithm. However, these results only apply to the non-strategic setting in which the jobs are released directly to the algorithm. Motivated by emerging areas(More)
Motivated by the rise of online auctions and their relative lack of security, this paper analyzes two forms of cheating in sealed-bid auctions. The first type of cheating we consider occurs when the seller spies on the bids of a second-price auction and then inserts a fake bid in order to increase the payment of the winning bidder. In the second type, a(More)
Intramedullary nailing preceded by canal reaming is the current standard of treatment for long-bone fractures requiring stabilization. However, conventional reaming methods can elevate intramedullary temperature and pressure, potentially resulting in necrotic bone, systemic embolism, and pulmonary complications. To address this problem, a reamer irrigator(More)
OBJECTIVE The differentiation of mesenchymal stem cells (MSCs) into chondrocytes provides an attractive basis for the repair and regeneration of articular cartilage. Under clinical conditions, chondrogenesis will often need to occur in the presence of mediators of inflammation produced in response to injury or disease. The purpose of this study was to(More)
We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and fat grafts. These tissues were selected because they not only possess mesenchymal progenitor cells and scaffolding properties, but also can be biopsied, genetically modified and returned to the(More)
Bone marrow contains mesenchymal stem cells (MSCs) that can differentiate along multiple mesenchymal lineages. In this capacity they are thought to be important in the intrinsic turnover and repair of connective tissues while also serving as a basis for tissue engineering and regenerative medicine. However, little is known of the biological responses of(More)
Facilitated endogenous repair is a novel approach to tissue engineering that avoids the ex vivo culture of autologous cells and the need for manufactured scaffolds, while minimizing the number and invasiveness of associated clinical procedures. The strategy relies on harnessing the intrinsic regenerative potential of endogenous tissues using molecular(More)