Ryan P. Taylor

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The autosomal dominant mutation in the human alphaB-crystallin gene inducing a R120G amino acid exchange causes a multisystem, protein aggregation disease including cardiomyopathy. The pathogenesis of cardiomyopathy in this mutant (hR120GCryAB) is poorly understood. Here, we show that transgenic mice overexpressing cardiac-specific hR120GCryAB recapitulate(More)
Synthesis of inducible heat shock protein 70 (HSP70) is impaired in aged animals following acute stresses including exercise. In this study we determined whether aging affects expression of this cytoprotective protein following chronic exercise participation. Male Fischer 344 rats, final ages 6 and 24 months, exercised identically for 10 weeks on a(More)
Exercise improves cardioprotection against ischemia-reperfusion in young animals, but has not been investigated in older animals that represent the population most likely to suffer an ischemic event. Therefore, we sought to determine the effects of aging on exercise-induced cardioprotection. Young, middle-aged, and old (4-, 12-, and 21-month-old) male F344(More)
OBJECTIVE The purpose of this study was to determine whether exercise training could precondition the myocardium against hydrogen peroxide (H(2)O(2))-induced damage. METHODS Male Fischer 344 rats ran on a treadmill for 9 weeks (60 min/day, 22 m/min, 6 degrees grade, 5 days/week). Isolated perfused working hearts from exercise trained (ET, n=8) and(More)
This paper describes a normally-open, self-encapsulated, valve for modulating refrigerant flow in a cryogenic cooling system. The valve consists of a micromachined die fabricated from a silicon-on-insulator wafer and a glass wafer, a commercially available piezoelectric stack actuator, and Macor ceramic encapsulation that has overall dimensions of 111 cm 3.(More)
This paper reports on a normally open piezoelectrically actuated microvalve for high flow modulation at cryogenic temperatures. One application envisioned is to control the flow of a cryogen for distributed cooling with a high degree of temperature stability and a small thermal gradient. The valve consists of a micromachined die fabricated from a(More)
Reactive oxygen species (ROS) have been reported to play a primary role in triggering the cardioprotective adaptations by some preconditioning procedures, but whether they are required for exercise-induced preconditioning is unclear. Thus in this study we used the free radical scavenger N-(2-mercaptopropionyl)glycine (MPG) to test the hypothesis that ROS is(More)
This paper describes a proportional valve that regulates viscous liquid media, intended for use with elastic reservoir/pumps in a portable drug delivery system. The valve is fabricated in a partially open state to permit flow even in the absence of applied power. At room temperature, piezoelectric actuation from-30 V to 60 V causes modulation of oil(More)
treatment by HD show a significantly high ammonia concentration in arterial blood, but not in venous blood. Muscle detoxification may contribute to limiting the rise of ammonia in this condition. contribution of various organs to ammonia formation: a review of factors determining the arterial ammonia concentration. of blood ammonia alterations in uraemic(More)
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