Ryan P. C. Chung

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A report that effects of butyrate on some cells may be mediated by activation of AMP-activated protein kinase (AMPK) prompted this study which examines if other AMPK activators can induce differentiation and inhibit proliferation of colon cancer cells in a manner similar to butyrate. Using induction of alkaline phosphatase as a marker, it was observed that(More)
Metal carbenes appended with two electron-donating groups, known as "donor/donor" carbenes, undergo diastereo- and enantioselective rhodium-catalyzed C-H insertion reactions with ether substrates to form benzodihydrofurans. Unlike the reactions of metal carbenes with electron-withdrawing groups attached, the attenuated electrophilicity enables these(More)
In this study, some valuation models that the most commonly applied to assess the value of intangible assets are reviewed. In the process of review, we highlight the key advantages and disadvantages of these models. Then a novel intangible asset valuation model is proposed which can integrate the strengths and overcome the weaknesses of income-based(More)
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