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In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase (PI3K) enzyme system. In the hypothalamus, insulin functions with leptin as an afferent adiposity signal important for the regulation of body fat stores and hepatic glucose metabolism. To test the hypothesis that hypothalamic(More)
—The Cray Gemini Interconnect has been recently introduced as the next generation network for building scalable multi-petascale supercomputers. The Cray XE6 systems, which use the Gemini Interconnect are becoming available with Message Passing Interface (MPI) and Partitioned Global Address Space (PGAS) Models such as as Global Arrays, Unified Parallel C,(More)
Gemini, the network for the new Cray XE/XK systems, features low latency, high bandwidth and strong scalability. Its hardware support for remote direct memory access enables efficient implementation of the global address space programming languages. Although the user Generic Network Interface (uGNI) provides a low-level interface for Gemini with support to(More)
Total Worker Health (TWH) was introduced and the term was trademarked in 2011 by the National Institute for Occupational Safety and Health (NIOSH) to formally signal the expansion of traditional occupational safety and health (OSH) to include wellness and well-being. We searched PubMed, PsycINFO, and other databases using keywords TWH, health promotion,(More)
1 Summary of the review Reading the title of the book, one might expect that it would focus on past, today and future of cyber security and cyber wars as well as its social aspects. This was at least my expectation. But the book is a very classical network security book and provides only technical details about various security issues. On the other hand,(More)
The design and synthesis of novel SGLT2 inhibitors: C-Glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties, " Access to 3-arylindoles through a tandem one-pot protocol involving dearomatization, a regioselective Michael addition reaction, and rearomatization,
,Studies of global change and other regional issues depend on ecological data collected at multiple st_,dy are_ or sites. An information system model is proposed for compiling diverse data from dispersed sources so that the data are consistent, complete, and readily available. The model includes investigators who collect and analyze field measurements,(More)
BACKGROUND Home care workers are a high-risk group for injury and illness. Their unique work structure presents challenges to delivering a program to enhance their health and safety. No randomized controlled trials have assessed the impact of a Total Worker Health™ program designed for their needs. METHODS/DESIGN The COMPASS (COMmunity of Practice And(More)
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