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Control of selectivity in the generation and reactions of oxonium ylides.
Dirhodium catalyzed reactions of aryl-substituted tetrahydropyranone diazoacetoacetates produce ylide intermediates that unexpectedly yield two oxabicyclo[4.2.1]-nonane diastereoisomers, but a singleExpand
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Competitive [2,3]- and [1,2]-oxonium ylide rearrangements. Concerted or stepwise?
The axial-equatorial conformational isomer distribution of the reactant diazoacetoacetate or its metal carbene intermediate is reflected in Rh(II) catalyzed oxonium ylide forming reactions ofExpand
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI:
A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.
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Scope and limitations of the Minisci reaction for the synthesis of aza-heterocycles
Attempts to prepare several classes of aza-heterocycles by application of the Minisci radical cyclisation reaction are described. Competing β-scission, hydrolytic cleavage and lactonisation reactionsExpand
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†
A significant proportion of genetic diseases, as well as many cancers, are associated with a particular type of mutation which gives rise to a premature termination codon (PTC) before the genuineExpand
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[[104-71-2] C16H16N2 (MW 236.32) InChI = 1S/C16H16N2/c1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16/h1-10,13-14H,11-12H2 InChIKey = QBAKBJNOARBSGP-UHFFFAOYSA-N (used as aExpand
Control of Selectivity in the Generation and Reactions of Oxonium Ylides.
The compounds (I), which bear a bulky aryl substituent, form the single diastereomers (II).