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- Publications
- Influence
Control of selectivity in the generation and reactions of oxonium ylides.
- Deana M Jaber, Ryan N Burgin, M. Hepler, P. Zavalij, M. Doyle
- Chemistry, Medicine
- Chemical communications
- 28 June 2011
Dirhodium catalyzed reactions of aryl-substituted tetrahydropyranone diazoacetoacetates produce ylide intermediates that unexpectedly yield two oxabicyclo[4.2.1]-nonane diastereoisomers, but a single… Expand
Competitive [2,3]- and [1,2]-oxonium ylide rearrangements. Concerted or stepwise?
- Deana M Jaber, Ryan N Burgin, Matthew Helper, P. Zavalij, M. Doyle
- Chemistry, Medicine
- Organic letters
- 6 April 2012
The axial-equatorial conformational isomer distribution of the reactant diazoacetoacetate or its metal carbene intermediate is reflected in Rh(II) catalyzed oxonium ylide forming reactions of… Expand
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI:…
- Victoria J. B. Gotham, Melanie C. Hobbs, Ryan N Burgin, D. Turton, C. Smythe, I. Coldham
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 7 January 2016
A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.
Scope and limitations of the Minisci reaction for the synthesis of aza-heterocycles
- Ryan N Burgin, S. Jones, B. Tarbit
- Chemistry
- 9 December 2009
Attempts to prepare several classes of aza-heterocycles by application of the Minisci radical cyclisation reaction are described. Competing β-scission, hydrolytic cleavage and lactonisation reactions… Expand
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†
A significant proportion of genetic diseases, as well as many cancers, are associated with a particular type of mutation which gives rise to a premature termination codon (PTC) before the genuine… Expand
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N,N′‐Bis(phenylmethylene)‐1,2‐Ethanediamine
- S. Jones, Ryan N Burgin
- Chemistry
- 14 March 2008
[[104-71-2] C16H16N2 (MW 236.32)
InChI = 1S/C16H16N2/c1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16/h1-10,13-14H,11-12H2
InChIKey = QBAKBJNOARBSGP-UHFFFAOYSA-N
(used as a… Expand
Control of Selectivity in the Generation and Reactions of Oxonium Ylides.
- Deana M Jaber, Ryan N Burgin, M. Hepler, P. Zavalij, M. Doyle
- Chemistry
- 22 November 2011
The compounds (I), which bear a bulky aryl substituent, form the single diastereomers (II).