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Reports indicate that postexercise heat loss is modulated by baroreceptor input; however, the mechanisms remain unknown. We examined the time-dependent involvement of adenosine receptors, noradrenergic transmitters, and nitric oxide (NO) in modulating baroreceptor-mediated changes in postexercise heat loss. Eight males performed two 15-min cycling bouts(More)
Many studies have aimed to identify the controllers of sweating using ventilated capsules with intradermal microdialysis. It is unclear, however, if the surface area covered by the capsule influences the observed response as a result of differences in the number of sweat glands affected by the infused pharmacological agent relative to the total glands(More)
47 We examined the separate and combined effects of plasma osmolality and baroreceptor loading 48 status on postexercise heat loss responses. Nine young males completed a 45-min treadmill 49 exercise protocol at 58±2% VO 2peak followed by a 60-min recovery. On separate days, 50 participants received 0.9% NaCl (ISO), 3.0% NaCl (HYP) or no infusion (natural(More)
Studies show that increases in plasma osmolality result in a delayed onset threshold of thermoeffector responses. However, it remains unclear if there are sex-related differences in the osmotically induced changes in both sweating and cutaneous vascular conductance (CVC). Nine young men and nine young women were passively heated (water-perfused suit) to(More)
The influence of peripheral factors on the control of heat loss responses (i.e., sweating and skin blood flow) in the postexercise period remains unknown in young and older adults. Therefore, in eight young (22 ± 3 years) and eight older (65 ± 3 years) males, we examined dose-dependent responses to the administration of acetylcholine (ACh) and methacholine(More)
2 Metabo-and baroreflex modulation of postexercise heat loss ABSTRACT 47 We examined whether sustained changes in baroreceptor loading status during prolonged 48 postexercise recovery can alter the metaboreceptors' influence on heat loss. Thirteen young 49 males performed a 1-min isometric handgrip exercise (IHG) at 60% maximal voluntary 50 contraction(More)
Keynote address: " Marfan syndrome and related disorders: from gene to therapy " Prof. 3 AED Pregnancy register, UK and Ireland Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The risk magnitude varies by AED exposure. We provide results from the UK and Ireland Epilepsy and Pregnancy Registers,(More)
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