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PURPOSE The aqueous humor nourishes the avascular tissues of the anterior segment, and the trabecular meshwork (TM) plays a role in the efflux of endogenous substances and xenobiotics from the aqueous humor. ATP (ATP)-binding cassette (ABC) transporter superfamily members respond to stressors such as hypoxia, cytokine signaling, and aging. The innate immune(More)
PURPOSE To determine whether soluble CD44 (sCD44), a likely biomarker of primary open-angle glaucoma (POAG), is internalized in cultured human trabecular meshwork (TM) cells and trafficked to mitochondria. METHODS In vitro, 32-kD sCD44 was isolated from human sera, biotinylated, and dephosphorylated. TM cells were incubated for 1 hour at 4°C with(More)
The onset of photophosphorylation was determined by exposing chloroplast thylakoids to either single or multiple light flashes of varying duration. In aggreement with the results of Ort et al. (Ort, D.R., Dilley, R.A. and Good, N.E. (1976) Biochim. Biophys. Acta 449, 108--124), the permeant buffer imidazole in the presence of valinomycin and K+ did not(More)
The role of brain cholecystokinin receptors in generation of anxiety states in mice and rats. Effect of caerulein and cholecystokinin antagonists on hypophyseal hormone secretion in single-housed and group-housed male rats. Does the personality of parents influence the physical activity of their children? In: oxidase, transcription factor AP-2 and(More)
PURPOSE CD44 plays major roles in multiple physiologic processes. The ectodomain concentration of the CD44 receptor, soluble CD44 (sCD44), is significantly increased in the aqueous humor of primary open-angle glaucoma (POAG). The purpose of this study was to determine if adenoviral constructs of CD44 and isolated 32-kDa sCD44 change intraocular pressure(More)
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