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We describe DPOCL, a partinl-order csnsal llnk planner that includes action decomposition. DPOCL builds directly on the SNLP algorithm (McAllester Rosenbiltt 1991), and hence is clear and simple, ud can readily be integrated with other SNLP extensions. In addition, DPOCL is specifically designed to handle partially specified action decompositions. Plan(More)
A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineering mouse models, but genetic and functional evidence for its oncogenic role in human lymphomas is needed. Here we describe a form of 'chronic active' BCR signalling that is required for cell survival in the(More)
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy. Constitutive nuclear factor (NF)-κB and JAK kinase signalling promotes malignant cell survival in these lymphomas, but the genetic basis for this signalling is incompletely understood. Here we(More)
Burkitt's lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL in developing countries, necessitating new strategies. The normal germinal centre B cell is the presumed cell of origin for both BL and diffuse large B-cell lymphoma (DLBCL), yet gene(More)
Respiratory infections, including Mycoplasma pneumoniae (Mp), contribute to asthma pathobiology. To date, the mechanisms underlying the increased susceptibility of asthmatics to airway Mp infection remain unclear. Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is a recently described large airway epithelial cell-derived molecule that was(More)
The Cognitive Dimensions of Notations framework has been created to assist the designers of notational systems and information artifacts to evaluate their designs with respect to the impact that they will have on the users of those designs. The framework emphasizes the design choices available to such designers, including characterization of the user's(More)
Current 3D game engines offer the potential for new types of interactive storytelling. In this paper, we discuss automated cinematography as it relates to interactive narratives in virtual worlds. Due to the interactive nature of these environments, automated camera controllers cannot fully utilize all of the idioms in the domain of cinematography. It is(More)
This article presents an approach to using cognitive models of narrative discourse comprehension to define an explicit computational model of a reader's comprehension process during reading, predicting aspects of narrative focus and infer-encing with precision. This computational model is employed in a narrative discourse generation system to select and(More)
Parasite-specific antibody responses to Neospora antigens were detected using the immunofluorescent antibody test (IFAT) and immunoblot analysis in select equine populations. For comparison, a naturally infected Neospora hughesi horse and an experimentally inoculated Neospora caninum horse were used. In addition, all samples were tested for antibodies to(More)
To examine the exquisite regulation of IgE-FcepsilonRI tyrosine phosphorylation by Lyn kinase that is stimulated by antigen-mediated cross-linking, we utilized co-expression of FcepsilonRI and Lyn in Chinese hamster ovary cells, which results in high basal levels of Lyn kinase activity and spontaneous phosphorylation of FcepsilonRI. We found that(More)