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Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest(More)
Previously we reported that a karyotypically silent t(4;14)(p16. 3;q32.3) translocation is present in about 25% of multiple myeloma (MM) tumors, and causes overexpression of FGFR3, which is 50 to 100 kb telomeric to the 4p16 breakpoints. Frequent FGFR3 kinase activating mutations in MM with t(4;14) translocations substantiate an oncogenic role for FGFR3. We(More)
In this paper, we describe a system for managing the hiring and assigning of Graduate Teaching Assistants (GTAs) to academic tasks based on the GTAs qualifications, preferences, and availability. This system is built using Constraint Processing techniques and is operated through web-based interfaces. Various versions of the prototype system have been in(More)
This report describes and documents observational results that arise from the playtesting­based evaluation of twenty­six computer games focused on science learning or scientific research. We refer to this little studied genre of computer games as science learning games (SLGs). Our goal was to begin to identify a new set of criteria, play mechanics, and play(More)
The quest for higher sensitivity and finer angular resolution in astronomy demands larger and more complex space imaging systems. This thesis presents the concepts developed for two different technologies that have the potential to contribute in improving the performance of space imaging systems. The first technology is precision pointing control(More)
We have designed and implemented a system for the management of Graduate Teaching Assistants (GTAs) in our department. The system is based on Constraint Processing techniques and is operated through web-based interfaces. The task is to assign GTAs, based on their qualifications, availability, and preferences, to academic tasks over a semester such as(More)
INTRODUCTION Disruption in bone homeostasis with increased osteoclastic resorption may lead to osteoporosis. HIV tat has been found to increase differentiation of precursor cells into osteoclast (OC) (1). Presence of soluble HIV proteins in virally suppressed HIV patients on ART may drive a bone resorption phenotype. We investigated the role of soluble HIV(More)
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