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The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of specific genes,Expand
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Open Chromatin Profiling in Mice Livers Reveals Unique Chromatin Variations Induced by High Fat Diet*
Background: Metabolic diseases result from a combination of multiple genetic and environmental factors. Results: High fat diet leads to chromatin remodeling in mice liver tissue in a strain-dependentExpand
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G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors
BackgroundThe formation of chromatin domains is an important step in lineage commitment. In human hematopoietic stem and progenitor cells (HSPCs), G9a/GLP-dependent H3K9me2 chromatin territories formExpand
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Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma
Background: Oligonucleotide drug development has revolutionised the drug discovery field. Within this field, ‘small’ or ‘short’ activating RNAs (saRNA) are a more recently discovered category ofExpand
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Publisher Correction: The current state and future directions of RNAi-based therapeutics
The use of the names for patisiran has been made consistent throughout the article in line with the journal style and typographical errors have been corrected.
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Persistent Inhibition of ABL Tyrosine Kinase Causes Enhanced Apoptotic Response to TRAIL and Disrupts the Pro-Apoptotic Effect of Chloroquine
TNF-Related Apoptosis Inducing Ligand (TRAIL) binds to and activates death receptors to stimulate caspase-8 and apoptosis with higher efficiency in cancer than normal cells but the development ofExpand
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Chromatin Profiling in Mice Livers Reveals Unique Chromatin Variations Induced by High Fat Diet *
Background: Metabolic diseases result from a combination of multiple genetic and environmental factors. Results: High fat diet leads to chromatin remodeling in mice liver tissue in a strain-dependentExpand
Author Correction: The current state and future directions of RNAi-based therapeutics
Errors in the alignment and structure of the siRNN and in the structure of the sisiRNA in the original version of Fig. 3 have been corrected.