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2-[(Diphenylmethyl) sulfinyl]acetamide (modafinil), prescribed principally to treat narcolepsy, is undergoing assessment for other neuropsychiatric disorders and medical conditions. The neurochemical substrates of modafinil are unresolved. We postulated that modafinil enhances wakefulness by modulating dopamine (DAT), norepinephrine (NET), or serotonin(More)
The pathomechanics, ligamentous damage, and degree of carpal instability in perilunate and lunate dislocations were analyzed by experimentally loading 32 cadaver wrists to failure. Thirteen perilunate and two lunate dislocations were produced. The mechanism of injury was extension, ulnar deviation, and intercarpal supination. These dislocations occurred in(More)
PURPOSE The purpose of this study is to report the predisposing factors, timing of symptoms, timing of diagnosis, causative organisms, source of infection, and visual outcome in cases of endogenous bacterial endophthalmitis. METHODS The records of 28 patients with endogenous bacterial endophthalmitis who presented to our combined ophthalmology and(More)
The radiobiology of osteoradionecrosis is a complex of cellular death and cellular functional impairments from radiation energy transfers. Four studies of irradiated patients and a data base from 536 patients with osteoradionecrosis revealed separate pathophysiologic conditions for osteoradionecrosis induced by early trauma, osteoradionecrosis induced by(More)
  • R P Johnson
  • 1980
Carpal injuries are confusing and treacherous. Understanding the mechanisms are important in diagnosis and treatment. The mechanisms of extension, intercarpal supination and ulnar deviation can lead to most of the fractures and dislocations of the carpus and distal radius. Internal fixation of some avulsion type fractures will stabilize the wrist. Most(More)
Heregulin beta1 (HRG), a combinatorial ligand for human growth factor receptors 3 and 4, is a regulatory polypeptide that promotes the differentiation of mammary epithelial cells into secretory lobuloalveoli. Emerging evidence suggests that the processes of secretory pathways, such as biogenesis and trafficking of vesicles in neurons and adipose cells, are(More)
Twenty-one adult patients with the clinical diagnosis of avascular necrosis (AVN) of the femoral head were examined with radionuclide angiography, planar bone scintigraphy, and single photon emission computed tomography (SPECT). A final diagnosis of AVN was established for 15 symptomatic patients with a total of 20 involved hips. SPECT and planar bone(More)
The os trigonum is an accessory bone of the foot found in 7% of the normal adult population. It is located at the posterolateral projection of the talus, and can occasionally give rise to symptoms of acute and chronic unexplained ankle pain. We report three patients, one with acute fracture and two with chronic ankle symptoms. Technetium 99 methylene(More)
The ligamentous anatomy of the wrist was analyzed by studying (1) 28 dissected human wrists, (2) and by examination of 19 wrist injuries created mechanically. Six volar intracapsular ligaments are described, two stabilizing the distal carpal row, three stabilizing the proximal carpal row and one stabilizing the proximal scaphoid pole. More specific(More)
Twenty-six unembalmed lower-leg specimens were mounted in an experimental test device with the foot placed at a fixed degree of pronation/supination, dorsiflexion/plantar flexion, or both. Torque versus rotation curves were determined as each foot was externally rotated to failure. Torsional stiffness was determined for the first 20 degrees of external(More)