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The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
TLDR
It is shown that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms, which provides insight into mechanisms of protein evolution under strong selection. Expand
Non-enzymatic proteins from snake venoms: a gold mine of pharmacological tools and drug leads.
TLDR
This review identifies research papers that have had significant impact on the life sciences and discusses how these findings have changed the course of science, and has also included the personal recollections of the original authors of these studies. Expand
Uridinediphosphate-glucuronosyltransferase (UDP-GT) Ontogeny and PCB Effects in Galliform Birds
TLDR
The profile of UDP-GT activity, in relation to the ontogeny of circulating T4 and triiodothyronine (T3) in quail, is consistent with UDP- GT playing a role in regulating circulating T 4 and with the perihatch peak in T3 stimulating the posthatch peakIn UDP-GBT activity. Expand
Venom extraction from anesthetized Florida cottonmouths, Agkistrodon piscivorus conanti, using a portable nerve stimulator.
TLDR
The method described produced consistent venom extraction, maximized yield by completely emptying the glands, potentially reduced animal stress by reducing time of conscious physical restraint, and decreased the likelihood of human envenomation. Expand
Venom gland transcriptomics for identifying, cataloging, and characterizing venom proteins in snakes.
Snake venoms are cocktails of protein toxins that play important roles in capture and digestion of prey. Significant qualitative and quantitative variation in snake venom composition has beenExpand
Snake bites and hemostasis/thrombosis.
TLDR
The large number of yet-to-be characterized venoms provides a vast potential source of novel toxins and subsequent cardiovascular therapeutics and diagnostic agents. Expand
Proteomic comparisons of venoms of long-term captive and recently wild-caught Eastern brown snakes (Pseudonaja textilis) indicate venom does not change due to captivity.
TLDR
It is shown that protein variation within LT and RC groups of snakes (Pseudonaja textilis) is high, thereby resulting in no discernible differences in venom composition between groups, and that venom composition may be correlated to geographic distribution. Expand
Proteomic Deep Mining the Venom of the Red-Headed Krait, Bungarus flaviceps
TLDR
The utility of a multifaceted approach toward unraveling the proteome of snake venoms, employed here, allowed detection of even minor venom components, in turn contributing to more effective treatment of krait bites. Expand
Neurotoxicity fingerprinting of venoms using on‐line microfluidic AChBP profiling
TLDR
It is demonstrated that venom interactions with AChBP correlate with the severity of neurotoxicity observed following human envenoming by different snake species, and a new in vitro analytic platform for rapidly investigating neurotoxic snake venom proteins is provided. Expand
Trophic Ecology of Insular Cottonmouth Snakes: Review and Perspective
TLDR
Two important pathways by which allochthonous marine productivity enters the terrestrial food web to support these insular cottonmouths are colonial bird rookeries and shore drift of carrion and detritus. Expand
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