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SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a(More)
Expression of chloroplast genes is primarily regulated posttranscriptionally, and a number of RNA elements, found in either the 5′- or 3′-untranslated regions (UTRs) of plastid mRNAs, that impact gene expression have been identified. Complex regulatory and feedback mechanisms influence both translation and protein accumulation, making assignment of roles(More)
The occurrence of highly conserved amyloid-forming sequences in Candida albicans Als proteins (H. N. Otoo et al., Eukaryot. Cell 7:776-782, 2008) led us to search for similar sequences in other adhesins from C. albicans and Saccharomyces cerevisiae. The beta-aggregation predictor TANGO found highly beta-aggregation-prone sequences in almost all yeast(More)
Recruitment of endosomal sorting complexes required for transport (ESCRTs) to the cytosolic face of endosomes regulates selective inclusion of transmembrane proteins into the lumenal vesicles of multivesicular bodies (MVBs). ESCRT-0, -I, and -II bind directly to ubiquitinated transmembrane cargoes of the MVB pathway, whereas polymerization of ESCRT-III at(More)
In this work, we propose a new platform to enable service providers, such as web site operators, on the Internet to block past abusive users of anonymizing networks (for example, Tor) from further misbehaviour, without compromising their privacy, and while preserving the privacy of all of the non-abusive users. Our system provides a privacy-preserving(More)
Anonymous communications networks, such as Tor, help to solve the real and important problem of enabling users to communicate privately over the Internet. However, in doing so, anonymous communications networks introduce an entirely new problem for the service providers -- such as websites, IRC networks or mail servers -- with which these users interact, in(More)
We propose a new, communication-efficient way for users to fetch multiple blocks simultaneously in Goldberg’s robust information-theoretic private information retrieval (IT-PIR) scheme. Our new multi-block IT-PIR trades off some Byzantine robustness to improve throughput without affecting user privacy. By taking advantage of the recent Cohn-Heninger(More)
CBX5, CBX1, and CBX3 (HP1α, β, and γ, respectively) play an evolutionarily conserved role in the formation and maintenance of heterochromatin. In addition, CBX5, CBX1, and CBX3 may also participate in transcriptional regulation of genes. Recently, CBX3 binding to the bodies of a subset of genes has been observed in human and murine cells. However, the(More)
The eukaryotic green algae, Chlamydomonas reinhardtii has been shown to be capable of producing a variety of recombinant proteins, but the true potential of this platform remains largely unexplored. To assess the potential of algae for the production of novel recombinant proteins, we generated a series of chimeric proteins containing a single chain antibody(More)
The cellular response to Nutlin-3, a small-molecule inhibitor of the p53 repressor MDM2, varies widely among human cancer-derived cell types. Whereas HCT116 colorectal carcinoma cells display sustained cell cycle arrest, BV173 leukemia cells undergo rapid apoptosis and other cell lines show an intermediate response. We found that the expression of the p53(More)