Ryan Hamilton

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Excess nutrient uptake leads to obesity, insulin resistance, and type 2 diabetes. Mammalian target of the rapamycin (mTOR), a major component of the nutrient-sensing pathway also regulates mitochondrial oxidative function. Rapamycin, a pharmacological inhibitor of mTOR, causes glucose intolerance and inhibits mitochondrial oxidative function. While a number(More)
CONTEXT Hop tests are functional tests that reportedly require strength, power, and postural stability to perform. The extent to which a triple-hop distance (THD) test measures each of these characteristics is relatively unknown. OBJECTIVE To determine the extent to which the THD predicts performance on clinical measures of power, strength, and balance in(More)
Vol. XLVI (June 2009), 410–420 410 © 2009, American Marketing Association ISSN: 0022-2437 (print), 1547-7193 (electronic) *Alexander Chernev is Associate Professor of Marketing, Kellogg School of Management, Northwestern University (e-mail: ach@ northwestern.edu). Ryan Hamilton is Assistant Professor of Marketing, Goizueta Business School, Emory University(More)
The human psyche is equipped with the capacity to solve problems using different mental states or mindsets. Different mindsets can lead to different judgment and decision making styles, each associated with its own perspective and biases. To change perspective, people can, and often do, switch mindsets. We argue, however, that mindset switching can be(More)
The idea that consumers use brands to express their identities has led many companies to reposition their products from focusing on functional attributes to focusing on how they fit into a consumer’s lifestyle. This repositioning is welcomed by managers who believe that by positioning their brands as means for self-expression, they are less likely to go(More)
We present our experience with QUIC, an encrypted, multiplexed, and low-latency transport protocol designed from the ground up to improve transport performance for HTTPS traffic and to enable rapid deployment and continued evolution of transport mechanisms. QUIC has been globally deployed at Google on thousands of servers and is used to serve traffic to a(More)
Diabetic peripheral polyneuropathy is associated with decrements in motor/sensory neuron myelination, nerve conduction and muscle function; however, the mechanisms of reduced myelination in diabetes are poorly understood. Chronic elevation of oxidative stress may be one of the potential determinants for demyelination as lipids and proteins are important(More)
Protein misfolding is considered to be a potential contributing factor for motor neuron and muscle loss in diseases like Amyotrophic lateral sclerosis (ALS). Several independent studies have demonstrated using over-expressed mutated Cu/Zn-superoxide dismutase (mSOD1) transgenic mouse models which mimic familial ALS (f-ALS), that both muscle and motor(More)
The mammalian target of rapamycin (mTOR) plays an important role in cardiac development and function. Inhibition of mTOR by rapamycin has been shown to attenuate pathological cardiac hypertrophy and improve the function of aging heart, accompanied by an inhibition of the cardiac proteasome activity. The current study aimed to determine the potential(More)
Comparing biological processes in closely related species with divergent life spans is a powerful approach to study mechanisms of aging. The oxidative stress hypothesis of aging predicts that longer-lived species would have lower reactive oxygen species (ROS) generation and/or an increased antioxidant capacity, resulting in reduced oxidative damage with age(More)