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The structural fluctuations specific to self-assemblies of biological molecules have been investigated further with ultrasonic techniques by using frog virus 3 (FV3). We compared the ultrasonic properties of complete FV3 virions and of several subparticles that may be obtained from this DNA virus: (i) the central nucleoprotein core versus its component DNA(More)
We examine the degree of compatibility between clients and their auditors to test whether companies systematically prefer specific auditors based on this criterion. Using both financial statements and narrative disclosures, we introduce two new measures of compatibility based on how similar a client is to other clients of the same auditor. Our results(More)
The thermal denaturation of the common strain of a rod-shaped plant virus, tobacco mosaic virus, has been investigated by differential scanning calorimetry, and compared to that of various aggregation states of its coat protein and to that of three other TMV strains. The state of the virions was monitored by electron microscopy and analytical(More)
The structural fluctuations specific to self-assembled biological systems have been investigated further with ultrasonic techniques by using two strains of tobacco mosaic virus (TMV), as well as the helical aggregate of the common strain protein and subassemblies of it. We confirmed our earlier conclusion that protein assemblies exhibit specific structural(More)
  • R Cerf, Y Dormoy
  • 1986
The increased ultrasonic absorption brought about by self-assembly of biomolecules is analyzed for the assembly process from the 20S aggregate to the helical rod of tobacco mosaic virus protein in solution, designated here as the 20S --> P-helix transition. The analysis is based on theoretical developments in ultrasonic relaxation spectrometry presented(More)
Ultrasonic and calorimetric studies of small homogeneously-sized DMPC unilamellar vesicles showed two thermal transitions at temperatures Tc1 and Tc2 (Tc2 greater than or equal to Tc1); Tc2 is close to the phase transition temperature, Tc, of large vesicles. The process at Tc2 is not a fusion of vesicles and is interpreted as characterizing an(More)
  • R Cerf
  • 1978
A simple and general model of reversible conformational changes in biopolymers that lends itself to accounting for cooperativity without resort to a detailed description of the elementary steps is presented. It is suggested that the model permits the description of transitions in specific instances in which long-range effects are present and no simplifying(More)