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Inflammation associated with obesity may play a role in colorectal carcinogenesis, but the underlying mechanism remains unclear. This study investigated whether the Wnt pathway, an intracellular signaling cascade that plays a critical role in colorectal carcinogenesis, is activated by obesity-induced elevation of the inflammatory cytokine tumor necrosis(More)
OBJECTIVE Variations in the intake of folate are capable of modulating colorectal tumorigenesis; however, the outcome appears to be dependent on timing. This study sought to determine the effect of altering folate (and related B vitamin) availability during in-utero development and the suckling period on intestinal tumorigenesis. DESIGN Female wildtype(More)
BACKGROUND p53 gene therapy has been examined in several clinical trials, however, the results of those trials have mostly been unsatisfactory due to the low efficacy of this therapy. Leptomycin B (LMB) is an antibiotic originally isolated from Streptomyces that has the ability to inhibit the export of proteins containing a nuclear export signal from the(More)
The Wnt pathway is a pivotal signaling cascade in colorectal carcinogenesis. The purpose of this work is to determine whether depletion of folate and other metabolically related B vitamins induces in vivo activation of intestinal Wnt signaling and whether this occurs in parallel with increased tumorigenesis. A hybrid mouse was created by crossing a(More)
BACKGROUND Recently, the use of histone deacetylase inhibitors (HDACI) with gene therapy has been shown to improve the effect of this therapy. The effectiveness of one of the novel HDACIs, FK228, was examined in adenovirus-mediated p53 gene therapy of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS The expression levels of coxsackie and(More)
OBJECTIVES Bundling human immunodeficiency virus (HIV) testing with tests for other infectious diseases such as hepatitis C, syphilis, or gonorrhea has been proposed as a method to recruit at-risk individuals into HIV testing. The objectives of this study were to determine (1) the types of at-risk clients who choose the rapid vs. standard HIV test when(More)
Targeting advertising on television is difficult due to limitations around ad tracking and ad delivery. This paper describes a new method of television advertising which can work with today’s state of the art broadcast television media. The method works by calculating a match score between historical buyer demographics and television(More)
We present an active badge system to test the efficacy of Jini as middleware for a system of small, mobile devices. Our system consists of badges that transmit infrared signals, detectors attached to fixed PC's serving as Jini clients, and a Jini server to keep track of the locations of all badges. A second type of Jini client can query the server and(More)
OBJECTIVES: We previously demonstrated that diaspirin crosslinked hemoglobin (DCLHb, Baxter Healthcare Corp.) improves systemic oxygen uptake in sepsis. Therefore, our objective was to study the effects of DCLHb on microcirculatory blood flow in septic rats. DESIGN: Prospective and randomized experimental study in a university-affiliated laboratory.(More)
Computer networks are subject to Distributed denial of Service (DDoS) attacks, where a single attacker instructs multiple subverted hosts (zombies) to consume the victim’s network resources. The idea presented here extends our initial work. We quantify the security of an enterprise network against denial of service (DoS) attacks by finding the minimum(More)