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Sera from 40 patients with newly diagnosed bladder cancer (28 superficial tumours (pTa and pT1) and 12 muscle-invasive tumours) were assessed by enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of soluble E-cadherin (sE-cadherin), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble(More)
A Web service is a software system designed to support interoperable application-to-application interactions over the Internet. Recently, there has been a growing interest in Web service composition, and some languages (e.g.. WSBPEL and BPML) for modeling the composition have been proposed. In this paper, we focus on security constraints of Web service(More)
PURPOSE To provide rationale for using phosphoinositide 3-kinase (PI3K) and/or mitogen-activated protein kinase (MAPK) pathway inhibitors to treat rhabdomyosarcomas, a major cause of pediatric and adolescent cancer deaths. EXPERIMENTAL DESIGN The prevalence of PI3K/MAPK pathway activation in rhabdomyosarcoma clinical samples was assessed using(More)
PURPOSE Rhabdomyosarcomas are a major cause of cancer death in children, described with MYCN amplification and, in the alveolar subtype, transcription driven by the PAX3-FOXO1 fusion protein. Our aim was to determine the prevalence of N-Myc protein expression and the potential therapeutic effects of reducing expression in rhabdomyosarcomas, including use of(More)
OBJECTIVE To determine the associations between the expression of waf-1 (a cyclin-dependent kinase inhibitor regulated by p53), p53, bcl-2 and tumour progression in prostate cancer. PATIENTS AND METHODS Samples of prostatic tissue were obtained by biopsy or at prostatectomy from 40 men (mean age 73 years, range 55-88) with histologically confirmed(More)
Over the past few years, technology drivers for processor designs have changed significantly. Media data delivery and processing – such as telecommunications, networking, video processing, speech recognition and 3D graphics – is increasing in importance and will soon dominate the processing cycles consumed in computer-based systems. This paper describes a(More)
Phenotypic analysis of lymphoproliferative disorders is now considered mandatory for accurate classification which is the basis for optimum patient management. This is presently carried out in most cases using a range of antibodies recognizing B and T-cell antigens effective in paraffin sections, and an antibody to CD 3 is currently a key member of such(More)
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