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In progressive viral infection, antiviral T cell function is impaired by poorly understood mechanisms. Here we report that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus (HIV)-specific CD4(+) T cells but not CD8(+) T cells in all categories of HIV-infected subjects evaluated, with the exception of(More)
Early events during acute human immunodeficiency virus type 1 (HIV-1) infection are critical in determining the course of disease progression. Cells of the innate and adaptive immune responses are involved in this acute response to infection; however, little is known about the coevolution of innate and adaptive effector cell populations during the initial(More)
Cathepsin K is a member of the papain superfamily of cysteine proteases and has been proposed to play a pivotal role in osteoclast-mediated bone resorption. We have developed a sensitive cytochemical assay to localize and quantify osteoclast cathepsin K activity in sections of osteoclastoma and human bone. In tissue sections, osteoclasts that are distant(More)
Successful anti-marijuana messages can be hypothesized to have two types of effects, namely persuasion effects, that is, a change in people's beliefs about using marijuana, and priming effects, that is, a strengthened correlation between beliefs and associated variables such as attitude and intention. This study examined different sets of anti-drug(More)
In this paper, we present a novel passive millimeter-wave (PMMW) imaging system designed using compressive sensing principles. We employ randomly encoded masks at the focal plane of the PMMW imager to acquire incoherent measurements of the imaged scene. We develop a Bayesian reconstruction algorithm to estimate the original image from these measurements,(More)
The integrative model of behavior prediction and priming theory were used to evaluate the effects of anti-marijuana advertisements in an experimental context. In 1 original study and 2 replications, 435 adolescents were randomly assigned to condition, and those in the experimental condition viewed 3 ads that challenged undesirable normative beliefs about(More)
This study uses an integrative model of behavioral prediction as an account of adolescents' intention to use marijuana regularly. Adolescents' risk for using marijuana regularly is examined to test the theoretical assumption that distal variables affect intention indirectly. Risk affects intention indirectly if low-risk and high-risk adolescents differ on(More)
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