Ruud Schoemaker

Learn More
Recombinant adenoviral vectors are broadly applied in gene therapy protocols. However, adenovector-mediated gene transfer has limitations in vivo. One of these is the low gene transfer rate into organs other than the liver after systemic intravenous vector injection. Local direct injection into the target organ has been used as one possible solution, but(More)
Cytokines can be functionally active across species barriers. Bovine IL-10 has an amino acid sequence identity with human IL-10 of 76.8%. Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human monocytes and dendritic cells. Peripheral blood monocytes were isolated from healthy donors, and used directly(More)
Many two-dimensional incompressible inviscid vortex flows can be simulated with high efficiency by means of the contour dynamics method. Several applications require the use of a hierarchical-element method (HEM), a modified version of the classical contour dynamics scheme by applying a fast multipole method, in order to accelerate the computations(More)
Background: Oligosaccharides in milk act as soluble decoy receptors and prevent pathogen adhesion to the infant gut. Milk oligosaccharides reduce infectivity of a porcine rotavirus strain; however, the effects on human rotaviruses are less well understood.Objective: In this study, we determined the effect of specific and abundant milk oligosaccharides on(More)
Prediction about how migrants move in the pre-border terrain is important for effective border control. In this paper we present a method to obtain permeability indicators for accessibility and concealment on the basis of geographical terrain features, derived from high resolution satellite data. The indicators are used to estimate the mobility of migrants.(More)
  • 1