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Genetic variant of the scavenger receptor BI in humans.
TLDR
Reduced SR-BI function was associated with altered platelet function and decreased adrenal steroidogenesis, and a family with a functional mutation in SR- BI was identified. Expand
Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis
TLDR
There is now evidence that hepatic SR-BI facilitates postprandial lipid metabolism, and that hepatics secretion of VLDL is dependent on ABCA1-mediated nascent HDL formation, suggesting remnant and HDL metabolism are more intimately intertwined in hepatic lipid metabolism than has previously been appreciated. Expand
Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo Published, JLR Papers in Press, October 22, 2007.
TLDR
Interestingly, HDL effectively competed for the association of β-VLDL in the presence as well as in the absence of SR-BI, indicating a second common recognition site in the metabolism of VLDL (remnants). Expand
Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels
TLDR
Macrophage ABCA1 and ABCG1 play a crucial role in the prevention of macrophage foam cell formation, whereas combined deletion only modestly influences atherosclerosis which is associated with an attenuated increase in WTD-induced plasma cholesterol and decreased proinflammatory CD4-positive T cell counts. Expand
Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice Published, JLR Papers in Press, August 16, 2004.
TLDR
In vivo and in vitro, SR-BI is the sole molecule mediating the selective uptake of CE from HDL by the liver and the adrenals, making it the unique target to modulate reverse cholesterol transport. Expand
The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2*
TLDR
It is demonstrated that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism, and an unexpected functional link between LXR and Reelin signaling is established. Expand
Scavenger receptors: friend or foe in atherosclerosis?
TLDR
It is proposed that the presence of scavenger receptors in macrophages is beneficial because they remove potential deleterious material from the arterial wall and could modulate in this way CD36-mediated atherosclerotic foam cell formation. Expand
Platelet Activation by Oxidized Low Density Lipoprotein Is Mediated by Cd36 and Scavenger Receptor-A
TLDR
A novel platelet-activating pathway stimulated by oxLDL that is initiated by the combined action of CD36 and SR-A is revealed. Expand
Scavenger Receptor BI Plays a Role in Facilitating Chylomicron Metabolism*
TLDR
It is concluded that SR-BI is important in facilitating chylomicron (remnant) metabolism and might function as an initial recognition site for chylomaticron remnants whereby the subsequent internalization can be exerted by additional receptor systems like the LDL receptor and LDL receptor-related protein. Expand
Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters A1 and G1
TLDR
It is reported here that targeted disruption of both ABCA1 and ABCG1 in mice, despite severe plasma hypocholesterolemia, leads to massive lipid accumulation and foam cell formation of tissue macrophages. Expand
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