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The increase in eosinophils at the site of antigen challenge has been used as evidence to suggest that this cell type plays a role in the pathophysiology of asthma. Aberrant production of several different cytokines, particularly interleukin (IL)-5, has been shown to result in eosinophilia. IL-5 influences the development and maturation of eosinophils in a(More)
Since lithium has been shown to inhibit release of iodine from the thyroid, we have investigated its therapeutic potential in thyrotoxicosis. Eight detailed (131)I kinetic studies were performed on seven thyrotoxic women and data was analyzed using a computer program. Lithium at serum levels of about 1 mEq liter decreased the loss of (131)I from the(More)
Choleragen, the pure protein from cholera toxin, stimulates steroid secretion by Y-1 adrenal tumor cells in culture. The secreted steroids are the same as seen after addition of adrenocorticotropic hormone. Half-maximal stimulation occurs at 15 pM; stimulation is essentially irreversible by washing and partially reversible (for about 1 hr) by antibody, and(More)
The antimicrotubular agents colchicine, vinblastine, and podophyllotoxin have been found to stimulate steroid production by Y-l adrenal tumor cells in culture. The amount of steroid secreted under the influence of these agents is comparable to the amount produced during maximal adrenocorticotropin (ACTH) stimulation. The steroid end products,(More)
To the Editor: Numerous lines of experimental evidence implicate IRS2 in insulin signal transduction in key insulinresponsive tissues, and the combination of insulin resistance and pancreatic beta cell failure of homozygous Irs2 knockout mice is highly reminiscent of both core abnormalities in human type 2 diabetes [1]. IRS2 is therefore a compelling(More)
The response to exogenous glucagon administration was examined in 5 moderately obese subjects (180±20% ideal body weight) and 5 normal weight controls. Changes in the plasma concentration of glucagon, insulin, glucose, free fatty acids, and β-hydroxybutyrate were observed after both a 1.0 µg/kg or 2.0 µg/kg bolus i.v. glucagon injection. At the lowest dose(More)