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Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations
Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration in an interim analysis of two ongoing… Expand
Microarray analysis of retinal gene expression in chicks during imposed myopic defocus
Purpose The retina plays an important regulatory role in ocular growth. To screen for new retinal candidate genes that could be involved in the inhibition of ocular growth, we used chick microarrays… Expand
Microarray analysis of retinal gene expression in Egr-1 knockout mice
Purpose We found earlier that 42 day-old Egr-1 knockout mice had longer eyes and a more myopic refractive error compared to their wild-types. To identify genes that could be responsible for the… Expand
Relative axial myopia in Egr-1 (ZENK) knockout mice.
- Ruth Schippert, E. Burkhardt, M. Feldkaemper, F. Schaeffel
- Medicine, Biology
- Investigative ophthalmology & visual science
PURPOSE Experiments in chickens have implicated the transcription factor ZENK (also known as Egr-1, NGFI-A, zif268, tis8, cef5, and Krox24) in the feedback mechanisms for visual control of axial eye… Expand
Changes in scleral MMP-2, TIMP-2 and TGFbeta-2 mRNA expression after imposed myopic and hyperopic defocus in chickens.
- Ruth Schippert, C. Brand, F. Schaeffel, M. Feldkaemper
- Biology, Medicine
- Experimental eye research
- 1 April 2006
Induction of myopia leads to a decreased glycosaminoglycan synthesis and smaller collagen fibrillar diameters, increased levels of gelatinase-A (MMP-2) and decreased amounts of tissue inhibitor of… Expand
Peripheral defocus does not necessarily affect central refractive development
PURPOSE Recent experiments in monkeys suggest that deprivation, imposed only in the periphery of the visual field, can induce foveal myopia. This raises the hypothesis that peripheral refractive… Expand
Results from a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherired Retinal Dystrophies (RD)
A Microarray Analysis of Retinal Gene Expression in Chickens When Axial Eye Growth Is Inhibited by Imposed Myopic Defocus
Effects Of Lens-wear On Fgf Receptor Isoform Expression In The Chick Scleral Layers