Ruth Schindler

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CONTEXT It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) is superior to symptom-guided therapy. OBJECTIVE To compare 18-month outcomes of N-terminal BNP-guided vs symptom-guided heart failure therapy. DESIGN, SETTING, AND PATIENTS Randomized controlled multicenter Trial of Intensified vs(More)
Sildenafil inhibits cGMP breakdown by phosphodiesterase 5. In vitro, increased cGMP levels inhibit cAMP breakdown by phosphodiesterase 3. It is uncertain, however, whether sildenafil increases biological effects of interventions increasing cAMP levels in vivo. The objective of the present study in 40 healthy male volunteers was to determine the existence(More)
BACKGROUND Secondary erythrocytosis results in increased shear stress in cyanotic congenital heart disease (CCHD), which may modify the balance between vasodilators and vasoconstrictors and affect systemic endothelial function. Because no data are available on systemic vasomotion, systemic endothelial function and nitric oxide (NO) availability were(More)
BACKGROUND Although the capability of extracorporeal treatments after administration of contrast media to prevent radiocontrast-induced nephropathy is controversial, haemodialysis is performed in many institutions after radiographic procedures. There are conflicting reports on the efficacy of different dialysers and treatment modalities to remove contrast(More)
Back pain in a haemodialysis patient with severe atherosclerosis Case A 75-year-old diabetic and hypertensive haemodialysis patient was referred to our clinic in 2006. He suffered from severe atherosclerosis, including coronary artery disease (myocardial infarction 1982, 1984 and 1998, coronary artery bypass graft 1998) and peripheral artery disease leading(More)
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