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A regulatory role for Sec tRNA[Ser]Sec in selenoprotein synthesis.
TLDR
TRNA([Ser]Sec) was found to be limiting for UGA translation under conditions of high selenoprotein mRNA in both a transient reporter assay and in cells with elevated GPx-1 mRNA, indicating that selenium-induced tRNA methylation is a mechanism of regulation of the synthesis ofselenoproteins.
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Nonenzymatic Functions of Acetylcholinesterase Splice Variants in the Developmental Neurotoxicity of Organophosphates: Chlorpyrifos, Chlorpyrifos Oxon, and Diazinon
TLDR
The results indicate that nonenzymatic functions of AChE variants may participate in and be predictive of the relative developmental neurotoxicity of organoph phosphates, and that the various organophosphates differ in the degree to which they activate this mechanism.
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Chlorpyrifos Affects Phenotypic Outcomes in a Model of Mammalian Neurodevelopment: Critical Stages Targeting Differentiation in PC12 Cells
TLDR
CPF exerts stage-specific effects, reducing DNA synthesis in the undifferentiated state, impairing development of the cholinergic phenotype at the start of differentiation, and promoting expression of the catecholaminergic phenotype both in Undifferentiated and differentiated cells.
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Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth.
TLDR
A single genetic alteration resulted in enhanced skeletal muscle adaptation after exercise, and this is likely through subtle changes in the resting phosphorylation state of growth-related kinases.
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Adverse Neurodevelopmental Effects of Dexamethasone Modeled in PC12 Cells: Identifying the Critical Stages and Concentration Thresholds for the Targeting of Cell Acquisition, Differentiation and…
TLDR
It is indicated that DEX directly disrupts neuronal cell replication, differentiation, and phenotype at concentrations below those required for the therapy of preterm infants, providing a mechanistic link between glucocorticoid use and neurodevelopmental sequelae.
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Selenium influences the turnover of selenocysteine tRNA([Ser]Sec) in Chinese hamster ovary cells.
TLDR
Primary studies indicated an accelerated decline in tRNA([Ser]Sec) derived from both the transfected and the native gene, providing additional insight into the levels of regulation that control the translation of selenium containing proteins in mammalian cells.
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Nutrient-Gene Interactions Selenoprotein-Deficient Transgenic Mice Exhibit Enhanced Exercise-Induced Muscle Growth 1
TLDR
A single genetic alteration resulted in enhanced skeletal muscle adaptation after exercise, and this is likely through subtle changes in the resting phosphorylation state of growth-related kinases.
The regulation of selenoprotein translation.
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