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The level of Salmonella contamination in retail chicken products was investigated bimonthly in two counties in the UK over 12 consecutive months. In total 325 chicken and 35 giblet samples were… Expand
BACKGROUND Veliparib (ABT-888) is a potent, orally bioavailable, small-molecule inhibitor of the DNA repair enzymes poly ADP-ribose polymerase-1 and -2. Veliparib enhances the efficacy of… Expand
BACKGROUND Patients with malignant melanoma often relapse after treatment with BRAF and/or mitogen-activated protein kinase kinase (MEK) inhibitors (MEKi) owing to development of drug resistance. … Expand
BACKGROUND S-222611 is a reversible inhibitor of EGFR, HER2 and HER4 with preclinical activity in models expressing these proteins. We have performed a Phase 1 study to determine safety, maximum… Expand
R. Dummer1, A. Guminski2, R. Gutzmer3, L. Dirix4, K. Lewis5, P. Combemale6, R. Herd7, M. Kaatz8, C. Loquai9, A. Stratigos10, H. Schulze11, R. Plummer12, T. Yi13, A.L.S. Chang14, F. Cornelis15, R.… Expand
TPS2611 Background: BAL101553 is the pro-drug of BAL27862, a novel small-molecule microtubule-targeting agent with potent activity in drug-refractory tumor models. It exerts antiproliferative effects… Expand