Ruth Newcombe

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A randomised double-blind, placebo-controlled trial of high-dose, pulsed intravenous methylprednisolone was carried out in 50 individuals with multiple sclerosis; 22 patients were in acute relapse and 28 had chronic progressive disease. After a baseline assessment using the Kurtzke functional and expanded disability status scales each patient was randomly(More)
Glucocorticoids (GCs) compromise the ability of hippocampal neurons to survive various insults, and do so, at least in part, by exacerbating steps in the glutamate/N-methyl-D-aspartate (NMDA)/calcium cascade of damage. As evidence, GCs impair uptake of glutamate by hippocampal astrocytes, the GC endangerment of the hippocampus is NMDA receptor dependent,(More)
Medical records of 363 patients who had a diagnosis of lumbar disc disease and were managed by a posterior approach lumbar discectomy over a 7 year period were reviewed: 33 patients had a preoperative diagnosis of diabetes, an incidence in this patient population of 9.1%. The results for these 33 patients who had a diagnosis of diabetes mellitus were(More)
Eight histopathologists, based at different hospitals, who had previously examined 100 consecutive colposcopic cervical biopsies were circulated with the results of the initial study. The slides were then 'reblinded' and re-examined by the pathologists who, as before, assigned them into one of six diagnostic categories. The degree of interpathologist(More)
This study determines the effectiveness of a new low-unit-cost support system in patients at very high risk of developing pressure sores. In a prospective randomised controlled trial, a low-pressure inflatable mattress and cushion system (Repose) was compared to a dynamic support mattress (Nimbus II) used in conjunction with an alternating-pressure cushion(More)
The capacity of patients with cerebral lesions to copy a picture of a cube, as opposed to a nonrepresentational figure of similar structural complexity, was examined. Patients with copying disability showed greater impairment for the cube than the noncube whereas patients without copying impairment and controls performed equally on the two figures. It was(More)
Bromocriptine is widely used in the treatment of hyperprolactinaemia. It has also been shown to be effective in reducing the size of large pituitary tumours, particularly those secreting prolactin. We describe CSF rhinorrhoea in two such patients during treatment with bromocriptine and believe that this complication developed as a result of contraction of(More)
The effect of an intravenous infusion of an aminoacid solution (Aminoplex 14) on gastric secretion is compared in healthy subjects and in duodenal ulcer patients. The acid secretory response was twice as high in duodenal ulcer patients than in normal subjects, 60 minutes after starting the infusion. Serum gastrin levels, although initially higher in(More)
Neurotrauma from snow-sports related injuries is infrequently documented in the literature. In Australia no collective data has ever been published. The aim of this study is to document the injury pattern of snow sports related neurotrauma admissions to The Canberra Hospital, the regional trauma centre for the Snowy Mountains. A computerised hospital record(More)