Learn More
The emergence of multi-drug and extensive drug resistance of microbes to antibiotics poses a great threat to human health. Although drug repurposing is a promising solution for accelerating the drug development process, its application to anti-infectious drug discovery is limited by the scope of existing phenotype-, ligand-, or target-based methods. In this(More)
MOTIVATION Similarity search is the foundation of bioinformatics. It plays a key role in establishing structural, functional and evolutionary relationships between biological sequences. Although the power of the similarity search has increased steadily in recent years, a high percentage of sequences remain uncharacterized in the protein universe. Thus, new(More)
  • R S Hauptman
  • 1994
Asthma is the most common chronic illness of Canadians, affecting from 10% to 15% of the population. Although much has been written about the underlying pathophysiology of asthma, and numerous guidelines have been published on asthma management, little time has been devoted to the clinical management of chronic asthma. This article will assist family(More)
  • 1