Ruth Freiermuth Knuchel

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The in vitro cytotoxicities of the four drugs most frequently used for intravesical chemotherapy (Adriamycin, epodyl, mitomycin C, Thiotepa) and epirubicin were compared using monolayers and multicellular tumor spheroids of the human bladder cancer cell line, MGH-U1. Adriamycin and epirubicin were most cytotoxic against monolayer cultures, whereas mitomycin(More)
The p21WAF/Cip and the p27Kip1 genes have been identified as inductors of cell cycle arrest at the G1-checkpoint. Alterations of both genes have been suggested to be involved in the development of a variety of human malignancies due to a loss of critical antiproliferative mechanisms. To evaluate the prognostic importance of these alterations for patients(More)
BACKGROUND Bone marrow (BM) niches are often inaccessible for controlled experimentation due to their difficult accessibility, biological complexity, and three-dimensional (3D) geometry. METHODS Here, we report the development and characterization of a BM model comprising of cellular and structural components with increased potential for hematopoietic(More)
182 Background: TMRSS2-ERG fusion is the most frequent genetic abberation in prostate cancer. Till now its expression is not associated with a poorer prognosis. In cell line models the fusion can be induced by exogenic factors as hormonal treatment or radiotherapy. Additionally its expression leads to different sensitivities to radiotherapy in different(More)
Soil quality is recognised as being a key parameter of sustainable agricultural management. Existing methods of life cycle impact assessment (LCIA) do not include any soil quality indicators other than soil organic matter content. This paper rectifies this omission by presenting Swiss Agricultural Life Cycle Assessment for Soil Quality (SALCA-SQ), a LCIA(More)
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