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The effect of daily forced swimming (15 min) of rats for 21 consecutive days on peripheral-type bentodiazepine receptors (PBR) was investigated. A significant reduction (-17%; p < 0.05) was observed in renal PBR in the stressed animals. A nonsignificant reduction of -18% was detected in adrenal PBR. The maximal binding capacity of [3H]PK 11195 was unaltered(More)
UNLABELLED The relations between cognition and autism severity, head size and intervention outcome, were examined. Change in cognitive level with intervention was measured in children with autism and compared to children with developmental disabilities (DD). Eighty-one children (mean age 25.9 months) with autism (n=44) and DD (n=37) were assessed at pre-(More)
The effect of 21 days of imipramine hydrochloride (10 mg/kg) and phenelzine sulfate (10 mg/kg) administration followed by a 7-day period of withdrawal on peripheral-type benzodiazepine receptors was studied in male Sprague-Dawley rats. Both imipramine and phenelzine down-regulated adrenal peripheral-type benzodiazepine receptors (-18% P < 0.05; and -32%, P(More)
The peripheral-type benzodiazepine receptor (PBR) plays a major role in steroidogenesis. This receptor is sensitive to endocrine changes and stress. Antidepressants have been demonstrated to modulate adrenal and hepatic PBR in rats. To evaluate the relationship between depression and PBR, we measured platelet PBR in untreated depressed patients (n = 14) in(More)
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