Ruta Shantere

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Genetic control of immune reactions has a major role in the development of rheumatic heart disease (RHD) and differs between patients with rheumatic fever (RF). Some authors think the risk of acquiring RHD is associated with the HLA class II DR and DQ loci, but other views exist, due to the various HLA-typing methods and ways of grouping cases. Our goal was(More)
The HLA system is being paid more and more attention because it is very significant in polymorphous immunological reactions. Several studies have suggested that genetic susceptibility to rheumatic fever (RF) and rheumatic heart disease (RHD) is linked to HLA class II alleles. We hypothesized that HLA class II associations within RHD may be more consistent(More)
Materials and methods We analysed 41 patients with newly diagnosed JIA (25 RF negative polyarthritis, 10 oligoarthritis, 5 undifferentiated and 1 psoriatic arthritis). To evaluate disease activity, clinical (disease type, number of active and inactive joints) and laboratory (CRP, ESR, TNF alfa, ANA titer, HLA B 27 antigen) data were recorded. The level of(More)
UNLABELLED Juvenile idiopathic arthritis (JIA) is a heterogeneous condition and therapeutic strategies vary in different JIA types. The routinely accepted practice to start with Sulphasalazine (SS) as the first line treatment in patients with HLA B27 positive JIA proves to be ineffective in a large proportion of children. OBJECTIVE to investigate HLA B27(More)
Methods The study included data from out-patient medical record on 69 JIA patients (45 children, 24 adults) who received ETN therapy during 2004 till 2010. Treatment efficacy was assessed using the ACR (American College of Rheumatology) Pedi 30, 50 and 70 response. Therapy was evaluated after 3, 6, 12 and 24 months (mo) of ETN treatment. Safety was assessed(More)
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