Russell P. Hall

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TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to neurosensory function remains to be elucidated. We recently reported TRPV4 as a critical component of the keratinocyte machinery that responds to ultraviolet B (UVB) and functions critically to convert the(More)
This is the second in a series of three papers describing cortisol and growth hormone secretion in air traffic controllers at work. Comparing controllers' average hormone levels across a large number of biological, psychological and occupational characteristics yielded few replicable differences. Comparing men with themselves across three repeated endocrine(More)
In this study we examined the effect(s) of race, sex socioecological stress, and habitual anger-coping systolic/diastolic blood pressure levels and risk for being classified hypotensive. A total of 495 black/white males and 511 black/white females, residing in high/low stress areas of Detroit, were classified in terms of high, medium, and low levels of(More)
We examined the effect of negative affect on changes in stimulated secretion of cytokines by blood monocytes and determined whether insulin resistance (IR), as indexed by the Homeostasis Model Assessment (HOMA), moderated these associations in 58 healthy men (aged 18-65 years). Blood samples and ratings of negative affect were collected at rest and 15min(More)
This is the first in a series of three reports on repeated endocrine studies in the working environment for a group of 416 air traffic controllers. Twenty-minute integrated concentrations for plasma cortisol and human growth hormone across five-hr work periods are described and compared with a selection of studies of normal males reported in the literature.(More)
The c-Jun NH(2)-terminal kinase (JNK) signaling cascade has been implicated in a wide range of diseases, including cancer. It is unclear how different JNK proteins contribute to human cancer. Here, we report that JNK2 is activated in more than 70% of human squamous cell carcinoma (SCC) samples and that inhibition of JNK2 pharmacologically or genetically(More)
The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH(2)-terminal kinase (pJNK), CYLD was decreased in a majority of the melanoma cell lines and tissues examined. Exogenous expression of CYLD but not its(More)
This final report in the series of three examines the relationships between physical health change, psychopathology and work responsiveness to cortisol and growth hormone secretion in air traffic controllers. In contrast to expectations, those who had the lowest rates of mild to moderate physical health change showed a modest tendency to have higher average(More)
Mice with epidermal deletion of JunB transcription factor displayed a psoriasis-like inflammation. The relevance of these findings to humans and the mechanisms mediating JunB function are not fully understood. Here we demonstrate that impaired JunB function via gene silencing or overexpression of a dominant negative mutant increased human keratinocyte cell(More)
BACKGROUND Major depressive disorder (MDD) and chronic heart failure (CHF) have in common heightening states of inflammation, manifested by elevated inflammation markers such as C-reactive protein. This study compared inflammatory biomarker profiles in patients with CHF and MDD to those without MDD. METHODS The study recruited patients admitted to(More)