Russell M Possley

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direct analysis without pretreatment of serum samples. Clin Chem 1998; 44:1947–50. 17. Ward SB, Sjostrom L, Ujhelyi MR. Comparison of the pharmacokinetics and in vivo bioaffinity of Digitab versus Digibind. Ther Drug Monit 2000;22:599– 607. 18. Allen G. The affinity of binding of digoxin to ovine anti-digoxin Fab (Digibind) preparations. Biologicals(More)
The luteotropic roles of prolactin and testosterone (or estradiol formed in luteal tissue) were investigated in hypophysectomized rats with homografts of granulosa lutein tissue. Using this approach, we could determine the effects of prolactin independently of estrogen, since granulosa lutein tissue does not produce estrogen de novo under these conditions.(More)
Tricalcium-phosphate-lysine delivery systems (TCPL) have been developed to release pharmaceuticals into the circulation, at a predictable rate, for prolonged periods of time. The objective of this study was to design an implantable TCPL system capable of delivering progesterone (P) for about two weeks and Estradiol (E) in a short burst that mimics the(More)
On the day after ovulation, the thecal tissue and associated mural granulosa lutein cells of the rabbit corpus luteum were separated from the granulosa lutein 'core' by dissection and these tissues were cultured separately or together (whole corpus luteum) in defined medium for 10 days on stainless-steel grids. The medium was changed completely every 24 h.(More)
Ceramic delivery systems (CDS) have been found to be useful carriers for chemical and biological materials allowing a constant release of these materials over prolonged periods of time. We reasoned that testosterone (TE) filled CDS could be utilized in the long-term treatment of androgen deficient patients. The specific objective of this study was to(More)
On Day 10 of pseudopregnancy, rabbits were given an i.v. injection of hCG (10-20 i.u.) that was sufficient to cause new ovulations and the loss of follicular oestradiol secretion. There was an immediate 3-4-fold rise in serum progesterone which returned to near prestimulation values (approximately 27 ng/ml) within 12 h in the presence of an implant(More)
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