Russell Keenan

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In certain subgroups of severely head-injured patients, the mortality rate remains unacceptably high. The authors describe a randomized, controlled trial of prophylactic pentobarbital therapy in a group of these patients. Pentobarbital was started as soon as possible after the head injury, regardless of the intracranial pressure (ICP), and was continued for(More)
The increase growth of health information systems has provided a significant way to deliver great change in medical domains. Up to this date, the majority of medical centres and hospitals continue to use manual approaches for determining the correct medication dosage for sickle cell disease. Such methods depend completely on the experience of medical(More)
Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B-cell acute lymphoblastic leukaemia. Our analysis identified a sub-group (∼30% of patients) with >2.37%(More)
Intelligent systems and smart devices have played the major role in improving the healthcare organisation in terms of continuous tele-monitoring therapy and maintaining telemedicine management system for sickle cell disease. The biggest challenge facing majority of patients is the fact that there is still a lack of communication with healthcare(More)
The authors report their experience in successfully treating a 15-week-old child who became comatose following a spontaneous intracerebral hemorrhage. It was initially believed that a tumor in the right frontal lobe caused the hemorrhage. Coagulation studies revealed abnormal results on presentation, and the problem was only partially corrected after an(More)
Glycerol kinase deficiency occurs either as a relatively benign isolated enzyme deficiency, or as part of a syndrome resulting from a microdeletion in the p21 region of the X chromosome associated with congenital adrenal hypoplasia and/or Duchenne muscular dystrophy. Developmental delay is a consistent feature of the microdeletion syndrome but not of the(More)
In a patient undergoing craniotomy for clipping of an anterior communicating artery aneurysm, sodium nitroprusside was used to lower systemic arterial blood pressure to 80/35 mm Hg (mean arterial blood pressure (MABP) = 50 mm Hg), at which time the electroencephalogram (EEG) changed abruptly from normal to a burst suppression pattern. At the onset of burst(More)
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