Russell Keenan

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We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia. GATA2 is a transcription factor that plays an essential role in gene regulation during vascular development and hematopoietic differentiation. Our findings indicate that(More)
The authors report their experience in successfully treating a 15-week-old child who became comatose following a spontaneous intracerebral hemorrhage. It was initially believed that a tumor in the right frontal lobe caused the hemorrhage. Coagulation studies revealed abnormal results on presentation, and the problem was only partially corrected after an(More)
The increase growth of health information systems has provided a significant way to deliver great change in medical domains. Up to this date, the majority of medical centres and hospitals continue to use manual approaches for determining the correct medication dosage for sickle cell disease. Such methods depend completely on the experience of medical(More)
Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B-cell acute lymphoblastic leukaemia. Our analysis identified a sub-group (∼30% of patients) with >2.37%(More)
Intelligent systems and smart devices have played the major role in improving the healthcare organisation in terms of continuous tele-monitoring therapy and maintaining telemedicine management system for sickle cell disease. The biggest challenge facing majority of patients is the fact that there is still a lack of communication with healthcare(More)
2 SUMMARY A site-specific, chronic reference dose (RfD) was developed for polychlorinated biphenyls (PCBs) in the Upper Hudson River through application of data-based uncertainty factors (UFs) based on toxicity data for PCBs in humans with long-term occupational exposures and toxicity data for Rhesus monkeys from long-term PCB oral dosing studies. The(More)