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A brief exposure to high concentrations of glutamate kills cultured forebrain neurons by an excitotoxic process that is dependent on Ca2+ influx through the NMDA receptor. In this study, we have measured striking changes in mitochondrial function during and immediately after intense glutamate receptor activation. Using indo-1 microfluorometry and a specific(More)
1. In cultures of rat forebrain neurones, mitochondria buffer glutamate-induced, NMDA receptor-mediated Ca2+ influx. Here, we have used the fluorescent calcium indicator, indo-1 AM to record [Ca2+]i from single cells. We varied either the glutamate concentration or the duration of exposure to investigate the cellular mechanisms recruited to buffer [Ca2+]i(More)
In mammalian peripheral organs, 3-hydroxyanthranilic acid oxygenase (3HAO), catalyzing the conversion of 3-hydroxyanthranilic acid to quinolinic acid, constitutes a link in the catabolic pathway of tryptophan to NAD. Because of the possible involvement of quinolinic acid in the initiation of neurodegenerative phenomena, we examined the presence and(More)
We report the detection of very high-energy γ-ray emission from the intermediate-frequency-peaked BL Lacertae object W Comae (z = 0.102) by VERITAS, an array of four imaging atmospheric-Cherenkov telescopes. The source was observed between January and April 2008. A strong outburst of γ-ray emission was measured in the middle of March, lasting for only four(More)
Experimental basal ganglia lesions were produced in order to examine the effect of neuronal loss on quinolinic acid (QUIN) metabolism. The latter was investigated by measuring the activities of QUIN's biosynthetic enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO) and its degradative enzyme, quinolinic acid phosphoribosyltransferase (QPRT). Striatal(More)
Intensity interferometry exploits a quantum optical effect in order to measure objects with extremely small angular scales. The first experiment to use this technique was the Narrabri intensity interferometer, which was successfully used in the 1970s to measure 32 stellar diameters at optical wavelengths; some as small as 0.4 milli-arcseconds. The advantage(More)