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Epigenetic remodeling of the fungal secondary metabolome.
Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiersExpand
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Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea).
Nine clerodane diterpenes, solidagoic acids C-I (1-7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from theExpand
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Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia.
High-throughput natural products chemistry methods have facilitated the isolation of eight new (1-8) and two known (9 and 10) beilschmiedic acid derivatives from the leaves of a Gabonese species ofExpand
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A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest.
Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone GExpand
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Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). TheseExpand
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Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis.
A phytochemical investigation of Monanthotaxis congoensis afforded eight polyoxygenated cyclohexenes as well as the known crotepoxide. Structures were determined using NMR, MS, and optical rotationExpand
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Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework.
High-throughput natural products chemistry methods have led to the isolation of three new (1-3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structuresExpand
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Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest.
Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3). The structures ofExpand
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Antibacterial chromene and chromane stilbenoids from Hymenocardia acida.
Six chromene stilbenoids and one chromane stilbenoid were isolated from the African tree Hymenocardia acida. Several were moderately active against methicillin-resistant Staphylococcus aureusExpand
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