Rupesh Dudhe

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In the last few decades, a lot of work has been done on thiazole ring to find new compounds related to this scaffold to act as antioxidant, analgesic, anti-inflammatory, antimicrobial, antifungal, antiviral, diuretic, anticonvulsant, neuroprotective, and antitumor or cytotoxic drug molecules with lesser side effects. This review presents the up to date(More)
Free radicals are well known for playing a dual role in our body- deleterious as well as beneficial. It includes a metabolic pathway for its generation. Oxidative stress in our body occurs due to excessive generation of free radicals and reduced level of antioxidants, but at low concentrations, these radicals help to perform normal physiological functions(More)
Article is based on the different pharmacological activity of the triazole ring, from a last decade a lot of work is going on, on the triazole ring , scientists develop a lot of new compounds related to this moiety and screened them for there different pharmacological activities to get a molecule which have good pharmacological activity and lesser side(More)
Many of the health benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves. These biological activities include effects promotion of wound healing, antifungal activity, hypoglycemic or antidiabetic effects, antiinflammatory, anticancer, immunomodulatory and gastroprotective properties. While the(More)
abstract: Nitrogen containing heterocyclic ring such as Pyrimidine is a promising structural moiety for drug designing. A series of 6-Bromo-3-(2-morpholino methyl amino)-6-substituted phenyl pyrimidine-4-yl-2H-chromone-2-one(6aM-6jM)&3-(2-((piperidine-1-yl)methylamino)-6substituted phenylpyrimidin-4-yl)-7-bromo-2H-chromone-2-one (6aP-6jP) have been(More)
A novel series of 6-bromo-3-(2-morpholino methyl amino)-6-substituted phenyl pyrimidine-4-yl-2H-chromone-2-one (6aM–6jM) and 3-(2-((piperidine-1-yl)methyl amino)-6- substituted phenylpyrimidin-4-yl)-6-bromo-2H-chromone-2-one (6aP–6jP) have been synthesized from 3-(2-amino-6-pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (5a–5j) which were synthesized from(More)
A novel series of 2-amino-4-(coumarin-3-yl)-6-substituted phenyl pyrimidines (5a–h) were synthesized from 3-acetylcoumarin (3). The structures of the synthesized compounds were elucidated by I.R., 1H NMR, 13C NMR, and Mass spectroscopic techniques. The synthesized compounds were screened for in vivo analgesic activities at a dose of 20 mg/kg body weight(More)
The role of the monoamines, serotonin in mental illnesses including depression is well recognized. All antidepressant drugs in clinical use increase acutely the availability of these monoamines at the synapse either by inhibiting their neuronal reuptake, inhibiting their intraneuronal metabolism, or increasing their release by blocking the α2 autoand(More)