• Publications
  • Influence
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep single-cellExpand
  • 510
  • 39
BRIT1/MCPH1 Links Chromatin Remodeling to DNA Damage Response
To detect and repair damaged DNA, DNA-damage-response proteins need to overcome the barrier of condensed chromatin to gain access to DNA lesions. ATP-dependent chromatin remodelling is one of theExpand
  • 172
  • 8
  • PDF
Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth
Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, weExpand
  • 27
  • 2
Targeting Human MicroRNA Genes Using Engineered Tal-Effector Nucleases (TALENs)
MicroRNAs (miRNAs) have quickly emerged as important regulators of mammalian physiology owing to their precise control over the expression of critical protein coding genes. Despite significantExpand
  • 36
  • 1
  • PDF
Genome-Wide Crispr-Cas9 Screen Identifies Functionally Relevant Micro-RNAs in FLT3-ITD+ AML
Mammalian microRNA expression is dysregulated in many human cancers, including hematologic malignancies. MicroRNAs are small non-coding RNAs that repress their target genes by binding to the 39 UTRExpand
MiR-155 Promotes FLT3-ITD-Induced Myeloproliferative Disease through Inhibition of Interferon Signaling
Introduction & Background : MicroRNA expression is dysregulated in many human cancers, including hematologic malignancies. Among hematologic malignancies, acute myeloid leukemia (AML) carries aExpand