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OBJECTIVE The aim of this study was to evaluate the prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation (AF). METHODS A cohort of 136 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy controls were enrolled. The coding exons and splice junctions of the Nkx2.5 gene(More)
—We investigate the problem of designing delay-aware joint flow control, routing, and scheduling algorithms in general multi-hop networks for maximizing network utilization. Since the end-to-end delay performance has a complex dependence on the high-order statistics of cross-layer algorithms, earlier optimization-based design methodologies that optimize the(More)
We attack the challenging problem of designing a scheduling policy for end-to-end deadline-constrained traffic with reliability requirements in a multihop network. It is well known that the end-to-end delay performance for a multihop flow has a complex dependence on the high-order statistics of the arrival process and the algorithm itself. Thus, neither the(More)
—Motivated by the low-jitter requirements of streaming multi-media traffic, we focus on the development of scheduling strategies under fading conditions that not only maximize throughput performance but also provide regular inter-service times to users. Since the service regularity of the traffic is related to the higher-order statistics of the arrival(More)
We consider the design of throughput-optimal scheduling policies in multi-hop wireless networks that also possess good mean delay performance and provide regular service for all links -- critical metrics for real-time applications. To that end, we study a parametric class of maximum-weight type scheduling policies with parameter α ≥ 0, called(More)
We study the optimal control of communication networks in the presence of heterogeneous traffic requirements. Specifically, we distinguish the flows into two crucial classes: inelastic for modeling high-priority, delay-sensitive, and fixed-throughput applications; and elastic for modeling low-priority, delay-tolerant, and throughput-greedy applications. We(More)
—In this paper, we study the design of joint flow rate control and scheduling policies in multi-hop wireless networks for achieving maximum network utility with provably optimal convergence speed. Fast convergence is especially important in wireless networks which are dominated by the dynamics of incoming and outgoing flows as well as the time sensitive(More)
In this paper, we study the design of joint flowrate control and scheduling policies in multihop wireless networks for achieving maximum network utility with provably optimal convergence speed. Fast convergence is especially important in wireless networks that are dominated by the dynamics of incoming and outgoing flows as well as the time-sensitive(More)
OBJECTIVE This study aimed to identify novel PITX2c mutations responsible for idiopathic atrial fibrillation. METHODS A cohort of 210 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy individuals used as controls were recruited. The whole coding exons and splice junctions of the PITX2c gene, which encodes(More)
Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia in humans and is responsible for substantial morbidity and mortality worldwide. Emerging evidence indicates that abnormal cardiovascular development is involved in the pathogenesis of AF. In this study, the coding exons and splice sites of the NKX2-5 gene, which encodes a(More)