Learn More
MOTIVATION Despite their success in identifying genes that affect complex disease or traits, current genome-wide association studies (GWASs) based on a single SNP analysis are too simple to elucidate a comprehensive picture of the genetic architecture of phenotypes. A simultaneous analysis of a large number of SNPs, although statistically challenging,(More)
Kriging is a popular analysis approach for computer experiment for the purpose of creating a cheap-to-compute "metamodel" as a surrogate to a computationally expensive engineering simulation model. The maximum likelihood approach is employed to estimate the parameters in the Kriging model. However, the likelihood function near the optimum may be flat in(More)
Some new statistics are proposed to test the uniformity of random samples in the multidimensional unit cube 0; 1] d (d 2). These statistics are derived from the number-theoretic methods or quasi-Monte Carlo methods for measuring discrepancy of points in 0; 1] d. Under the null hypothesis that the samples are i.i.d. and have a uniform distribution in 0; 1] d(More)
Fractional factorial designs are popular and widely used for industrial experiments. Generalized minimum aberration is an important criterion recently proposed for both regular and non-regular designs. This paper provides a formal optimization treatment on optimal designs with generalized minimum aberration. New lower bounds and optimality results are(More)
The aim of this paper is to present a functional analysis of a diffusion tensor tract statistics (FADTTS) pipeline for delineating the association between multiple diffusion properties along major white matter fiber bundles with a set of covariates of interest, such as age, diagnostic status and gender, and the structure of the variability of these white(More)
[1] Future climate change is expected to affect ecosystem-atmosphere CO 2 exchange, particularly through the influence of temperature. To date, however, few studies have shown that differences in the response of net ecosystem CO 2 exchange (NEE) to temperature among ecosystems can be explained by differences in the photosynthetic and respiratory processes(More)
Organisms usually cope with change in the environment by altering the dynamic trajectory of gene expression to adjust the complement of active proteins. The identification of particular sets of genes whose expression is adaptive in response to environmental changes helps to understand the mechanistic base of gene-environment interactions essential for(More)
Oral diseases are major public health problems that impact people from early childhood. However, children's oral hygiene in China remains a severe problem due to inadequate education on oral hygiene behavior and parents' lack of knowledge about their childrens' dental condition. To address these problems, we propose DAYA, a system consisting of a(More)