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This study aims to investigate the role of impact angles on the de-agglomeration performance of powders for inhalation. Agglomerates of a model drug mannitol were impacted at customized impaction throats containing two angles (15-75 degrees and 45-45 degrees) or a single angle (15 degrees, 45 degrees and 90 degrees) using various air flow rates. The mass(More)
The objective of this study is to investigate the effect of device design of the Aerolizer® on the aerosolization of a carrier-based dry powder inhaler formulation (Foradile®). The Aerolizer was modified by reducing the air inlet size and mouthpiece length to 1/3 of the original dimensions, or by increasing the grid voidage. Aerosolization of the powder(More)
Carrier-based dry powder inhalers (DPIs) are widely used for rapid and convenient delivery of drug to the site of action. This work aimed to predict powder aerosolisation in DPIs through numerical modelling. A multi-scale modelling technique based on the combined computational fluid dynamics (CFD) and discrete element method (DEM) approach was developed.(More)
We hypothesize that the USP induction port may de-agglomerate carrier-free powder emitting from dry powder inhalers (DPIs). Aerosols emitting from a range of DPIs (Spinhaler®, Turbuhaler® and OsmohalerTM) and induction ports (USP throat, straight tube, Alberta idealized mouth-throat geometry (AG)) were sized by laser diffraction. Total drug recovery was(More)
The design of a dry powder inhaler device has significant influence on aerosol performance; however, such influence may be different between the drug-only and carrier-based formulations. The present study aims to examine the potential difference on the dispersion between these distinct types of formulations, using Aerolizer® as a model inhaler with the(More)
The US pharmacopeia (USP) and Alberta throats were recently reported to cause further de-agglomeration of carrier-free powders emitted from some dry powder inhalers (DPIs). This study assessed if they have similar influences on commercially available carrier-based DPIs. A straight tube, a USP throat, and an Alberta throat (non-coated and coated) were used(More)
  • Javan D Tjakra, Jie Bao, Nicolas Hudon, Runyu Yang
  • 2012
This paper aims to develop an approach to model the collective dynamics features on bidisperse particulate systems. The modeling of particulate behavior is based on stochastic approach, in particular Markov chains. The Markov chain operator is constructed using data generated from DEM simulations and is used to represent the system dynamical behavior. The(More)
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