Runsheng Wang

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The Hippo pathway regulates organ size and tumorigenesis in Drosophila and mammals and is altered in a variety of human cancers, yet it remains unclear if the Hippo pathway is of prognostic significance to cancer patients. Here we show that the key targets of Hippo signaling, transcriptional coactivators Yki and Yap, play a conserved role in promoting(More)
Presenilins (PS1/PS2) regulate proteolysis of beta-amyloid precursor protein (betaAPP) and affect its intracellular trafficking. Here, we demonstrate that a PS1-interacting protein, phospholipase D1 (PLD1), affects intracellular trafficking of betaAPP. Overexpression of PLD1 in PS1wt cells promotes generation of betaAPP-containing vesicles from the(More)
Hyperspectral images exhibit strong dependencies across spatial and spectral neighbors, which have been proved to be very useful for hyperspectral image classification. State-of-the-art hyperspectral image classification algorithms use the dependencies in a heuristic way or in probabilistic frameworks but impose unreasonable assumptions on observed data. In(More)
Presenilins (PS) are required for gamma-secretase cleavage of multiple type I membrane proteins including the amyloid precursor protein and Notch and also have been implicated in regulating intracellular protein trafficking and turnover. Using genetic and pharmacological approaches, we reveal here a unique function of PS in the pigmentation of retinal(More)
This paper presents a novel approach based on contextual Bayesian networks (CBN) for natural scene modeling and classification. The structure of the CBN is derived based on domain knowledge, and parameters are learned from training images. For test images, the hybrid streams of semantic features of image content and spatial information are piped into the(More)
Presenilins (PS1/PS2) play a critical role in proteolysis of beta-amyloid precursor protein (beta APP) to generate beta-amyloid, a peptide important in the pathogenesis of Alzheimer's disease. Nevertheless, several regulatory functions of PS1 have also been reported. Here we demonstrate, in neuroblastoma cells, that PS1 regulates the biogenesis of beta(More)