Runhuai Yang

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In this paper, the development of an automated patch clamp system for cellular electrical information is reported. The system involves several developments that enable the following tasks: “pipette and cell localization”, “pipette engaging”, “gigaseal”, and “break-in”. The system enables us to engage(More)
Optical modulation of nervous system becomes increasingly popular as the wide adoption of optogenetics. For these applications, upconversion materials hold great promise as novel photonic elements. This study describes an upconversion based strategy for combinatorial neural stimulation both in vitro and in vivo by using spectrum-selective upconversion(More)
An experimental and numerical investigation was carried out on the performance of a single-wheel travelling over various kinds of loose soil, including dry sand, wet sand, and mud. The experiments were conducted using a testbed equipped with a displacement transducer, a torque sensor, etc., to get the information on sinkage, driving torque, and drawbar(More)
In this paper, a study of an all-terrain wheeled mobile robot which is a complex multi-body mechanism is presented. An effective approach for kinematics modeling of the robot traversing uneven terrain has been proposed. Denavit-Hartenberg algorithms and differential kinematics are derived for the individual wheel motions in contact with the terrain. The(More)
Recent advances in patch clamp system have demonstrated that a visual-based micromanipulation strategy can benefit to perform electrophysiological recording automatically. In this paper, the design and implementation of a micromanipulation system with the visual-based identification are reported. The system is able to manipulate a patch clamp pipette to the(More)
A novel approach utilizing current feedback for the cytoplasmic microinjection of biological cells is proposed. In order to realize the cytoplasmic microinjection on small adherent cells (diameter < 30 μm and thickness < 10 μm), an electrical model is built and analyzed according to the electrochemical properties of target cells. In this study, we have(More)
Conventional patch clamp techniques require complex manual work. Automated patch clamp systems have been recently developed to eliminate the need of manual handling, but these systems can only perform recordings on suspended cells and require cell dissociation for recordings on adherent cells. Here, we develop a systematic approach to apply electrical(More)
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