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GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.
TLDR
Study of an AA population allowed evaluation of these associations at higher genomic resolution than is possible in a EA population, owing to the much lower LD across these loci in AAs. Expand
Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity
TLDR
The results suggest that the insertion polymorphism leads to increased SLC6A1 promoter activity because, in part, of creation of an enhancer element when present as multiple copies when present in multiple copies. Expand
Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer
TLDR
Genetic evidence is presented leading to hypothesize a possibility of PIGR to function as the EBV nasopharyngeal epithelium receptor via IgA-EBV complex transcytosis failure and increase the susceptibility of populations in endemic areas to develop NPC. Expand
Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
TLDR
Owing to the low level of LD and presence of recombination hotspots, SLC6A1 may be an example of a problematic gene for association and haplotype tagging-based genetic studies. Expand