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EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES
TLDR
The hexane fraction from M. siamensis flowers inhibited cell proliferation via the suppression of WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 Cells. Expand
Effects of Saraphi (Mammea siamensis) flower extracts on cell proliferation and Fms-like tyrosine kinase 3 expression in leukemic EoL-1 cell line
TLDR
Hex fraction demonstrated the strongest cytotoxic activity with IC50 and total cell numbers of Hex fraction treated EoL-1 cells were decreased in a time- and dose-dependent manner at the concentration of IC20 value, suggesting that Hex extraction of M. siamensis flower is a promising approach for new anti-leukemic drug candidates. Expand