Rune V. Petersen

Learn More
Blood from two male and two female donors was exposed at 37degrees for 4 hr to concentrations of 60.0, 6.0, 0.6, and 0.06 mug of a widely used plasticizer, bis (2-ethylhexyl) phthalate, per milliliter of blood. The bis(2-ethylhexyl) phthalate was solubilized with polysorbate 80. Appropriate polysorbate and nonpolysorbate controls also were established.(More)
Vaccine adjuvants activate the innate immune system and thus influence subsequent adaptive T-cell responses. However, little is known about the initial immune mechanisms preceding the adjuvant-induced differentiation of T-helper (Th) cells. The effect of a T-helper 1 (Th1) adjuvant, dimethyldioctadecylammonium liposomes with monophosphoryl lipid-A(More)
The in vivo release of norethindrone from a biodegradable steroid-polymer conjugate was studied in rats. The drug-polymer conjugate, consisting of [3H]norethindrone coupled via a 17-carbonate bond to poly-N5-(3-hydroxypropyl)-L-glutamine was administered to female rats by subcutaneous injection. The in vivo release of steroid, determined by measuring the(More)
Permeation of cations through silicone rubber tubing was measured, and the effect of an ion-exchange resin on the cation diffusion was determined. Silicone rubber has been used as a biomedical polymer and shows a very low solubility to ionizable species. Correlations between the calculated diffusion coefficients, with and without the resin, depended on the(More)
The sensitivity of a bacterial bioluminescent acute toxicity test was compared to the sensitivity of the USP mouse safety, rabbit intramuscular implantation, rabbit intracutaneous, mouse systemic injection, and the MEM elution tissue culture tests. A variety of industrial plastics were used to evaluate the comparative sensitivities. Additional tests were(More)