Rune Bruhn Jakobsen

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BACKGROUND Most lesions of articular cartilage do not heal spontaneously and may lead to secondary osteoarthritis. It is not known whether the optimistic reports on the short and long-term results of several different cartilage repair techniques are based on sound methodological quality. METHODS We performed a literature search in MEDLINE, CINAHL, the(More)
The purpose of this study was to evaluate the efficiency of using mesenchymal stem cells (MSC) in a hyaluronan scaffold for repair of an osteochondral defect in rabbit knee. Bone marrow was harvested from the posterior iliac crest in 11 New Zealand White rabbits. MSC were isolated and cultured in autologous serum for 28 days and transferred to a hyaluronan(More)
Treatment of focal lesions of the articular cartilage of the knee using chondrocytes in a hyaluronic acid (HA) scaffold is already being investigated in clinical trials. An alternative may be to use mesenchymal stem cells (MSC). We have compared articular chondrocytes with MSC from human bone marrow (BM) and adipose tissue (AT), all cultured in HA(More)
This information is current as of May 12, 2010 Supplementary Material http://www.ejbjs.org/cgi/content/full/90/10/2069/DC1 http://www.ejbjs.org/cgi/content/full/90/10/2069#responses Letters to The Editor are available at Reprints and Permissions Permissions] link. and click on the [Reprints and jbjs.org article, or locate the article citation on to use(More)
Lesions of articular cartilage do not heal spontaneously. One treatment strategy would be to make cartilage in the laboratory by directed chondrogenic differentiation of mesenchymal stem cells (MSCs). To promote our understanding of the molecular control of chondrogenesis, we have compared the changes in microRNAs (miRNAs) during in vitro chondrogenesis of(More)
Adipose-tissue-derived stem cells (ASCs) have received considerable attention due to their easy access, expansion potential, and differentiation capacity. ASCs are believed to have the potential to differentiate into neurons. However, the mechanisms by which this may occur remain largely unknown. Here, we show that culturing ASCs under active proliferation(More)
The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium. In general, this leads to a phenotype lacking some of the cardinal features of native articular chondrocytes and their(More)
OBJECTIVES Previously, we identified a 10-year cohort of protocols from applications to the Norwegian Medicines Agency 1998-2007, consisting of 196 drug trials in general practice. The aim of this study was to examine whether trial results were published and whether trial funding and conflicts of interest were reported. DESIGN Cohort study of trials with(More)
The authors reported Harris Hip Scores (HHS) with corresponding standard deviations (SDs) to assess hip pain and function in the two treatment groups. There were no significant differences in mean HHS scores at any followup time. The largest difference in HHS between the two groups was recorded after 6 months, with a mean HHS (SD) of 76.18 (12.5) in the IF(More)