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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
TLDR
This study evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir and favipiravir against a clinical isolate of 2019-nCoV in vitro.
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
TLDR
Evaluated the antiviral effect of HCQ against SARS-CoV-2 infection in comparison to CQ in vitro and concluded that CQ appears to be the drug of choice for large-scale use due to its availability, proven safety record, and a relatively low cost.
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
TLDR
Six currently available and licensed anti-influenza drugs against SARS-CoV-2 are evaluated and it is suggested that arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate of COVID-19 patients.
Anti-SARS-CoV-2 Potential of Artemisinins In Vitro
TLDR
Evaluated anti-SARS-CoV-2 activities of nine artemisinin-related compounds in vitro and carried out a time-of-drug-addition assay to explore their antiviral mode of action; a pharmacokinetic prediction model was established to predict the therapeutic potential of selected compounds against COVID-19 and revealed lumefantrine showed therapeutic promise due to high plasma and lung drug concentrations after multiple dosing.
Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika
TLDR
Nitazoxanides and its bioactive metabolite, tizoxanide, have anti-ZIKV potential in vitro, and it is identified that they exerts antiviral effect possibly by targeting the viral postattachment step.
Host Calcium Channels and Pumps in Viral Infections
TLDR
Impeding virus-induced abnormal intracellular Ca2+ homeostasis is becoming a useful strategy in the development of potent antiviral drugs.
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